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Despite our ambivalence, sales of psychiatric drugs amounted to more than seventy billion dollars in 2010. In the past few years, one pharmaceutical giant after another—Glaxo Smith Kline, Astra Zeneca, Novartis, Pfizer, Merck, Sanofi—has shrunk or shuttered its neuroscience research facilities.
They have become yet another commodity that consumers have learned to live with or even enjoy, like S. Clinical trials have been halted, lines of research abandoned, and the new drug pipeline has been allowed to run dry.
Nortriptyline itself also possesses antidepressant activity. Additional hydroxy metabolites apparently are active as well.
When Cade diluted the uric acid by adding lithium, the guinea pigs fared better; when he injected them with lithium alone, they became sedated.
He noticed the same effect when he tested lithium on himself, and then on his patients.
In other words, it’s an antidepressant that works on both serotonin and norepinephrine neurotransmitters.
It is not the only antidepressant to do this, but SNRIs are a smaller class of drugs than those that just effect serotonin alone (like Prozac).
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If you live in the US, you’ve probably seen all the commercials for the new and pastel-pink-coloured antidepressant Pristiq.